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目的探讨DNA免疫吸附治疗儿童系统性红斑狼疮并发血小板减少性紫癜的疗效。方法对1例系统性红斑狼疮并发血小板减少性紫癜患儿进行DNA免疫吸附治疗,观察相关症状及抗核抗体(ANA)、抗双链DNA抗体(抗ds-DNA)、抗Smith抗体(抗Sm)、抗心磷脂抗体(ACL)及血常规、肝肾功能、电解质、免疫球蛋白等指标。结果DNA免疫吸附治疗后,患儿全身淤点淤斑等症状明显改善,血小板升至正常范围内,同时血液中的有形成分白细胞、红细胞无明显减低,血清IgG回落,补体回升,血清ANA、抗ds-DNA、ACL-IgM、SSA逐渐恢复正常。结论DNA免疫吸附治疗对系统性红斑狼疮并发血小板减少性紫癜有较好的疗效,其远期疗效还需长期随访。
Objective To investigate the therapeutic effect of DNA immunosorbent on children with systemic lupus erythematosus and thrombocytopenic purpura. Methods One child with systemic lupus erythematosus complicated with thrombocytopenic purpura was treated with DNA immunosorbent assay and the related symptoms were observed. Anti-nuclear antibody (ANA), anti-dsDNA (anti-dsDNA) ), Anti-cardiolipin antibodies (ACL) and blood, liver and kidney function, electrolytes, immunoglobulins and other indicators. Results After DNA immunosorbent therapy, the symptoms such as eczema and ecchymosis were significantly improved in children with thrombocytopenia and thrombocytopenia rose to the normal range. At the same time, the visible components of blood in the blood leucocytes and erythrocytes were not significantly reduced, serum IgG decreased, complement rose, serum ANA, Anti-ds-DNA, ACL-IgM, SSA gradually returned to normal. Conclusion DNA immunosorbent assay has a good curative effect on patients with systemic lupus erythematosus and thrombocytopenic purpura, and its long-term follow-up is still needed.