作者于1987年5～8月,用48h的体外微量法和9d的连续培养法测定了泰国恶性疟原虫现场分离株对略萘啶、氯喹及甲氟喹的敏感性,目的在于确定和评估三种抗疟药的有效程度。 疟原虫取自泰国北碧府法霍帕越色纳医院收治的43例恶性疟病人,年龄15～63岁,初始原虫率在0.11～1.0％之间,受试前7d均未服抗疟药,并经尿检确定。体外测定微量法按照WHO1982年改进的Rieck- In May-August 1987, the susceptibility of the P. falciparum isolate to thalidomide, chloroquine and mefloquine in Thailand was determined using a 48 h in vitro microdialysis method and a 9-day continuous culture method with the aim of identifying and evaluating three Effectiveness of antimalarial drugs. Plasmodium was collected from 43 cases of falciparum malaria patients from Fahoppa Hospital in Kanchanaburi Province of Thailand. The age ranged from 15 to 63 years. The initial protozoan rate was between 0.11 and 1.0%. The anti-malaria drug was not given for 7 days before the test , And determined by urine test. In vitro determination of trace method According to the WHO revised in 1982 Rieck-