目的寻找直肠癌患者术中止血的最有效方法。方法直肠癌患者74例,随机分为观察组(38例,输注冷沉淀)和对照组(36例,输注全血),比较两组输注前后血常规、凝血指标变化情况。结果观察组输注冷沉淀后与输注前比较,患者血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)明显缩短,差异有统计学意义(P<0.01),纤维结合蛋白(Fn)明显增加,差异有统计学意义(P<0.01);输注后观察组PT、APTT、Fn优于对照组,差异有统计学意义(P<0.01)。结论冷沉淀应用于直肠癌手术中,是一种良好的生物止血剂,可用于防止伤口感染、止血和促进愈合,且能够降低肿瘤复发率。 Objective To find the most effective method of intraoperative hemostasis in patients with rectal cancer. Methods Totally 74 patients with rectal cancer were randomly divided into observation group (38 cases, infusion of cryoprecipitate) and control group (36 cases, whole blood transfusion). The changes of blood routine and coagulation index before and after the infusion were compared. Results Compared with those before infusion, PT and APTT in the observation group were significantly shorter than those before the infusion (P <0.01), and fibronectin (P <0.01). The PT, APTT and Fn in the observation group were better than those in the control group after infusion, the difference was statistically significant (P <0.01). Conclusion Cold sedimentation is a good biological hemostatic agent for rectal cancer surgery. It can be used to prevent wound infection, hemostasis and promote healing, and can reduce tumor recurrence rate.