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目的:探讨RegⅣ蛋白在大肠癌发生发展中的作用.方法:免疫组织化学染色检测60例临床大肠腺癌组织及其癌旁组织和30例大肠腺瘤组织中RegⅣ蛋白的表达.结果:RegⅣ蛋白在癌旁组织、腺瘤和癌组织中的阳性表达率分别为75.00%、86.6%和63.33%,差异具有统计学意义(P<0.01).RegⅣ蛋白与大肠癌进展无显著相关性(P>0.05).RegⅣ蛋白的表达与性别、年龄、肿瘤分级和有无淋巴结转移均无显著性差异(P>0.05).结论:RegⅣ蛋白是一个在大肠癌发生发展中差异表达的肿瘤相关基因,可能在腺瘤向腺癌转化的早期阶段起作用,而与肿瘤的进展无关.
Objective: To investigate the role of Reg ¢ ñ protein in the development of colorectal cancer.Methods: The expression of Reg ¢ ñ protein in 60 cases of colorectal adenocarcinoma and its adjacent tissues and 30 cases of colorectal adenoma was detected by immunohistochemical staining.Results: The positive rates of VEGF in adjacent tissues, adenomas and carcinomas were 75.00%, 86.6% and 63.33%, respectively, with statistical significance (P <0.01) .RegIV protein had no significant correlation with the progression of colorectal cancer (P> 0.05) .The expression of RegⅣ protein had no significant difference with sex, age, tumor grade and lymph node metastasis (P> 0.05) .Conclusion: RegⅣ protein is a tumor-related gene that is differentially expressed in the development and progression of colorectal cancer, Adenoma in the early stages of adenocarcinoma transformation, but has nothing to do with the progress of the tumor.