患儿　女，８岁（图１），以左膝关节逐渐增粗１年余，局部肿胀，皮肤青紫，走路跛行来诊。患儿自出生至今曾３次发生无诱因的高热惊厥入院治疗，用退热、激素药物治疗无效，每需物理降温。从不出汗，夏季喜在水泥地面上睡或浸泡在水中。喜咬手指，但不觉疼痛，注射打针从来不 Children, 8 years old (Figure 1), to the left knee gradually thicken more than 1 year, local swelling, skin bruising, walked to visit the clinic. Since the birth of children has been 3 times without inducing fever convulsion admission therapy, with fever, hormone therapy ineffective, each physical cooling. Never sweat, summer like sleeping on the concrete floor or soaked in water. Hi biting fingers, but do not feel pain, injection injection never