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报导一例男性,36岁,用氯喹作抗疟预防治疗,开始剂量每日100—200毫克,7个月后因一次发热而氯喹量增至每日600毫克。服药后第9个月出现下肢易疲劳并逐渐加重,同时出现咀嚼、说话及阅读的易疲劳性与复视,第10个月入院。检查发现患者消瘦,手掌及足跖黄染;双下肢远端与近端运动缺损、腱反射消失,咀嚼、发音及眼运动易疲劳。辅助检查:心电图、脑脊液、眼电图、视网膜电图均正常。有低血色素、小细胞性、低铁性及再生较弱的贫血,红细胞320万,白细胞3,000,粒细胞减少。来源于肌肉的血清酶轻度增加。对氯喹的代谢
Reported a male, 36 years old, used chloroquine as an anti-malarial prophylaxis and started doses of 100-200 mg daily. After 7 months, the amount of chloroquine increased to 600 mg daily due to a fever. The first nine months after taking the lower extremity fatigue and gradually increased, while chewing, speaking and reading of the fatigue and diplopia, the first 10 months admission. Examination found that patients wasting, palm and plantar yellow dye; distal and proximal lower extremity motor deficit, tendon reflex disappeared, chewing, pronunciation and eye movement fatigue. Auxiliary examination: ECG, cerebrospinal fluid, eye diagram, electroretinogram are normal. A hypochromic, small cell, low iron and less regenerative anemia, red blood cells 3.2 million, 3,000 white blood cells, neutropenia. Serum enzymes from muscle slightly increased. Chloroquine metabolism