碘酞六醇(Iohexol)协作研究始于1988年7月,止于1991年3月,美国的23个医学中心参加。根据有否糖尿病或慢性肾功能不全,将接受心脏造影的临床稳定的患者分层,然后随机采用碘酞六醇或泛影葡胺钠(Sodium meglucamine diatrizoate)。糖尿病指须要使用胰岛素或者口服降糖药者。慢性肾功能不全指血清肌酐≥1.5mg/dl而且有相应病史者。凡有下列情况者已经剔除:1个月内肾功能改变,饮食能控制的糖尿 Iohexol collaborative research began in July 1988, ending in March 1991, the United States to participate in 23 medical centers. Patients with clinically stable heart undergoing angiography were stratified according to whether they had diabetes or chronic renal insufficiency and randomized to receive either sodium or potassium iodide or sodium meglucamine diatrizoate. Diabetes refers to the need to use insulin or oral hypoglycemic agents. Chronic renal insufficiency refers to serum creatinine ≥ 1.5mg / dl and have a corresponding history. Who have the following conditions have been removed: 1 month renal changes, diet can control diabetes