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目的 研究血清S10 0蛋白、TPS(组织多肽特异性抗原 )在恶性黑色素瘤 (恶黑 )中的表达情况及其临床价值。方法 ELISA法动态检测 4 2例恶黑患者血清S10 0蛋白和TPS水平。结果 血清S10 0蛋白灵敏度 (Sensitiv ity ,Se)为 35 .7% ,特异度 (Specificity ,Sp) 95 .2 % ;TPSSe为 19.1% ,Sp 94 .2 %。联合检测S10 0蛋白和TPS ,平行试验 (paralleltest,两者中任何一个阳性即认为诊断试验阳性 )评价 :Se 4 7.6 % ,Sp 89.4 % ;系列试验 (serialtest,两者同时阳性 ,诊断试验才认为是阳性 ) :Se 7.1% ,Sp 10 0 % ;病情进展 ,血清S10 0蛋白血清水平和灵敏度增高 ;治疗前血清S10 0蛋白水平高于正常的患者 ,对治疗的反应较差 ;血清S10 0蛋白水平进行性升高提示复发或转移及不良预后 ,TPS在这些方面作用不明显。结论 平行试验评价血清S10 0蛋白和TPS有助于恶黑诊断 ,动态测定血清S10 0蛋白能够反映恶黑病情变化
Objective To study the expression and clinical value of serum S10 0 protein and TPS (Tissue Polypeptide Specific Antigen) in malignant melanoma. Methods Serum levels of S10 0 protein and TPS were detected by ELISA in 42 cases of black evil patients. Results Serum S10 0 had a sensitivity of 35.7% and a specificity of 95.2%. TPSSe was 19.1% and Sp 94.2%. The combination of S10 0 protein and TPS, parallel test (positive for any of the two, considered diagnostic tests positive). Evaluation: 7.6% for Se 4 and 89.4% for Sp 89.4%. Serial tests, both positive and diagnostic, Is positive): Se 7.1%, Sp 10 0%; The progress of the disease, serum S10 0 serum levels and increased sensitivity; serum pretreatment S10 0 protein levels higher than normal patients, poor response to treatment; serum S10 0 protein Progressive increase prompted the recurrence or metastasis and poor prognosis, TPS in these aspects is not obvious. Conclusions A parallel test to evaluate serum S10 0 protein and TPS contributes to the diagnosis of malignant tumor. The dynamic determination of serum S10 0 protein can reflect the change of ill condition