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胶质瘤干细胞(glioma stem cells,GSCs)生存和自我更新依赖由多种可溶性分子以及间质细胞组成的微环境。基质金属蛋白酶(MMPs)是由多种锌离子依赖性酶组成的能降解细胞外基质蛋白的重要酶类,MMPs激活与恶性胶质瘤的生长、侵袭以及转移密切相关。PEX是大多数MMPs在羧基末端都含有的血红素结合蛋白样结构域,近年来研究证明PEX是MMPs内源性抑制剂,抑制MMPs的活性从而影响胶质瘤干细胞微环境,破坏胶质瘤干细胞的相对稳态来阻止胶质瘤的增殖、侵袭和转移。PEX基因的发现给胶质瘤的治疗带来了新思路。因此,本文就PEX基因与胶质瘤干细胞微环境的关系作一综述。
The survival and self-renewal of glioma stem cells (GSCs) rely on the microenvironment composed of various soluble molecules and stromal cells. Matrix metalloproteinases (MMPs) are important enzymes that can degrade extracellular matrix proteins by a variety of zinc-dependent enzymes. The activation of MMPs is closely related to the growth, invasion and metastasis of malignant gliomas. PEX is the heme-binding protein-like domain of most MMPs at the carboxyl terminus. In recent years, it has been proved that PEX is an endogenous inhibitor of MMPs and inhibits the activity of MMPs and thus affects the glioma stem cell microenvironment and the destruction of glioma stem cells The relative steady state to prevent glioma proliferation, invasion and metastasis. The discovery of PEX gene brings a new idea to the treatment of glioma. Therefore, this article reviews the relationship between PEX gene and glioma stem cell microenvironment.