不同国家和地区急性胰腺炎的发病率、死亡率和病变程度有明显差异。欧美国家明显地高于我国等亚洲国家,这可能与饮食成分结构有紧密关系。欧美等国人群的食物中所含蛋白质、脂肪的比例明显高于亚洲各国,动物实验显示喂养高脂高蛋白食物的动物所诱发的急性胰腺炎明显较喂给基础食物者重,而且死亡率也高。其机理可能与高营养下胰腺内蛋白质及脂肪水解酶类的合成适应性增多有关;也可能是高脂高蛋白质食物影响了胰腺细胞膜的稳定性和完整性所致。另外,还可能与磷脂酶A的活性及自由基反应在胰腺内的增强有紧密关 In different countries and regions, the incidence of acute pancreatitis, mortality and pathological changes were significantly different. Europe and the United States was significantly higher than China and other Asian countries, which may be closely related with the composition of diet. The proportion of protein and fat contained in food in Europe, the United States and other countries is significantly higher than that in other Asian countries. Animal experiments show that acute pancreatitis induced by animals fed high-fat and high-protein foods is significantly heavier than those fed with basic foods and the mortality rate is also high high. The mechanism may be related to the increased adaptive synthesis of proteins and lipolytic enzymes in the pancreas under high nutrition. It may also be due to the stability and integrity of the pancreatic cell membrane affected by high fat and high protein foods. In addition, it may also be related to phospholipase A activity and free radical reaction in the pancreas to enhance the close