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目的探索自体硬腭粘膜修补眼睑缺损的效果。方法动物实验：３只狗的１２只眼睑，自体硬腭粘膜修补人为眼睑缺损。观察２２周，眼睑外形修复。病理检查上皮形态、厚度恢复，结缔组织内细胞及毛细血管数量呈正常水平，胶原纤维束排列整齐。临床研究：收治１３例（１５只睑）眼睑缺损患者，其中上睑３例，下睑８例，上、下睑２例。肿瘤导致缺损５例，外伤造成缺损８例。完全缺损６只睑，２／３缺损４只睑，１／２～１／３缺损５只睑。年龄２２～７９岁。采用脂肪区中厚硬腭粘膜植片修补眼睑缺损。结果术后观察平均１１．３个月。治愈８只睑，显效３只睑，改善４只睑。无严重并发症发生。结论自体硬腭粘膜移植不仅能替代睑板起支架作用，同时可修补睑结膜缺损。
Objective To explore the effect of autologous hard palate mucosa repair eyelid defect. Methods Animal experiment: Twelve eyelids of 3 dogs were repaired with artificial hard palate mucosa for artificial eyelid defect. Observation of 22 weeks, eyelid shape repair. Pathological examination epithelial morphology, thickness recovery, the number of connective tissue cells and capillaries was normal, collagen fibers arranged in neat rows. Clinical study: 13 patients (15 eyelids) eyelid defect patients, including 3 cases of upper eyelid, lower eyelid in 8 cases, upper and lower eyelid in 2 cases. Tumor led to defects in 5 cases, trauma caused by defects in 8 cases. 6 complete eyelid defects, 2/3 defects 4 eyelids, 1/2 ~ 1/3 defects 5 eyelids. Age 22 ~ 79 years old. Fat area with thick hard palate mucosal graft repair eyelid defect. Results The average postoperative observation was 11.3 months. Eight eyelids were cured, three eyelids markedly improved, and four eyelids improved. No serious complications occurred. Conclusion Autologous hard palate mucosa transplantation can not only replace the tarsal plate as a scaffold, but also repair the conjunctival defect.