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目的 探讨新疆维吾尔族2型糖尿病(T2DM)患者自主神经病变与心率变异(HRV)及其他脏器受损的关系。 方法 选择确诊为 T2DM的 150 例维吾尔族住院患者,其中单纯糖尿病(SDM)组72例,合并心血管疾病的糖尿病(DC)组78例,病程 <5年组54例,5~10年组51例,>10年组45例。正常对照(NC)组为健康的维吾尔族人 60 名,全部进行 24 h动态心电图及 HRV分析。 结果 T2DM患者HRV均小于NC组(t’= 6.5366~9.5677, P<0.05 ),DC组的 HRV较 SDM组低(t=4.0791~8.9233,P<0.05 ),病程>5 年的两组患者所有正常 R R间期的标准差值均低于病程<5年组(t=7.5935~10.631,P<0.05 )。 结论 HRV是早期判断维吾尔族 T2DM患者自主神经病变最准确而又最敏感的方法,可能对是否合并心脏缺血性病变有提示作用。
Objective To investigate the relationship between autonomic neuropathy and heart rate variability (HRV) and other organ damage in type 2 diabetic patients with type 2 diabetes in Xinjiang Uygur Autonomous Region. Methods A total of 150 Uighur inpatients with T2DM were enrolled in this study. Among them, 72 were in the simple diabetic group (SDM), 78 in the diabetes mellitus (DC) group with cardiovascular disease, 54 in the 5-year group and 51 in the 5-to-10 group Cases,> 10 years group of 45 cases. Sixty healthy Uyghur people were included in the normal control (NC) group, all of them undergoing 24-h dynamic electrocardiogram and HRV analysis. Results The HRV of T2DM patients was lower than that of NC patients (t ’= 6.5366-9.5677, P <0.05). The HRVs of DC patients were lower than those of SDM patients (t = 4.0791-8.9233, P <0.05) The standard deviation of normal RR interval was lower than the duration of <5 years (t = 7.5935 ~ 10.631, P <0.05). Conclusion HRV is the most accurate and sensitive method for judging the autonomic neuropathy in Uigur patients with T2DM at early stage, which may be helpful for the diagnosis of ischemic heart disease.