Sensititre(R)结核药敏板检测结核分枝杆菌药敏的方法学研究

来源 :河北医科大学学报 | 被引量 : 0次 | 上传用户:b479676614
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目的 评价使用Sensititre(R)结核药敏板进行结核分枝杆菌药敏试验的价值.方法 分别使用Sensititre(R)结核药敏板和L-J比例法对124株结核分枝杆菌复合群的临床分离株进行药敏试验(包括异烟肼、利福平、乙胺丁醇、链霉素、氧氟沙星、莫西沙星、阿米卡星、利福布汀、对氨基水杨酸、乙硫异烟肼、环丝氨酸、卡那霉素),并将两法结果进行比较.结果 使用Sensititre(R)结核药敏板和L-J比例法对124株结核分枝杆菌复合群的临床分离株进行异烟肼、利福平、乙胺丁醇、链霉素、氧氟沙星、莫西沙星、阿米卡星、利福布汀、对氨基水杨酸、乙硫异烟肼、环丝氨酸、卡那霉素等12种药物的敏感性试验.其敏感度、特异度均较好.各药的符合率都达到了90.0%以上.结论 使用Sensititre(R)结核药敏板所得的药敏结果与传统的L-J比例法有较高的一致性,且其检测时间较短、操作更为简单,同时还能获得抗结核药物的最低抑菌浓度值.
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