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目的：比较５ 只家兔单剂量口服甲苯咪唑微丸及片剂后的药动学与生物利用度。方法：采用ＲＰＨＰＬＣ 法测定血药浓度，３Ｐ８７ 程序计算药动学参数。结果：微丸的Ｃｍａｘ、Ｔ１／２ 、ＡＵＣ分别为６４３．４９ ｎｇ·ｍｌ－ １ 、１ ．０５ ｈ、８ １７０ ．９４ ｈ·ｎｇ·ｍｌ－１ 。结论：微丸与片剂的ＡＵＣ有统计学显著性差异（ Ｐ＜０ ．０５），相对生物利用度为５２８ ．６０ ％ 。
Objective: To compare the pharmacokinetics and bioavailability of 5 single rabbits with oral mebendazole and its tablets. Methods: Plasma concentration was determined by RPHPLC method. Pharmacokinetic parameters were calculated by 3P87 program. Results: The Cmax, T1 / 2 and AUC of pellets were 643.49 ng · ml-1, 1, respectively. 05 h, 8 170. 94 h · ng · ml-1. Conclusion: The AUC of pellets and tablets has a statistically significant difference (P <0 .05), the relative bioavailability of 528. 60%.