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目的探讨环磷酰胺冲击疗法联合激素对肾病综合征的治疗效果。方法 84例肾病综合征患者,随机分为实验组和对照组,各42例。实验组给予环磷酰胺冲击疗法联合激素治疗,对照组采用常规激素疗法,观察两组患者的临床效果。结果实验组治疗总有效率明显高于对照组(P<0.05);实验组药物不良反应率为4.8%明显低于对照组的16.7%,差异具有统计学意义(P<0.05)。结论环磷酰胺冲击疗法联合激素对肾病综合征的治疗效果好,药物不良反应发生率低,值得临床关注。
Objective To investigate the therapeutic effect of cyclophosphamide combined with hormones on nephrotic syndrome. Methods 84 patients with nephrotic syndrome were randomly divided into experimental group and control group, 42 cases in each group. The experimental group was given cyclophosphamide shock therapy combined with hormone therapy, the control group with conventional hormone therapy, the clinical efficacy of two groups were observed. Results The total effective rate of the experimental group was significantly higher than that of the control group (P <0.05). The adverse reaction rate of the experimental group was 4.8% lower than that of the control group (16.7%), the difference was statistically significant (P <0.05). Conclusion cyclophosphamide shock therapy combined with hormones treatment of nephrotic syndrome is good, the incidence of adverse drug reactions is low, it deserves clinical attention.