目的:探讨妊娠后期硫酸镁使用对仔鼠学习记忆能力的影响。方法:将孕鼠分为药物组与对照组,药物组于孕晚期给予硫酸镁尾静脉注射,对照组尾静脉注射相同容积的生理盐水,于出生21d和115d对所有仔鼠利用Morris水迷宫进行学习记忆能力测试。结果:出生21d和115d,药物组仔鼠水迷宫实验逃避潜伏期与对照组相比均未见明显差异(P>0.05)。结论:孕后期使用硫酸镁对实验动物子代的学习记忆能力无明显影响。 Objective: To investigate the effect of magnesium sulfate in late gestation on learning and memory abilities of offspring. Methods: The pregnant rats were divided into the drug group and the control group. The drug group was given intravenous injection of magnesium sulfate in the third trimester of pregnancy, the same volume of normal saline in the tail vein of the control group, Morris water maze Learning and memory ability test. Results: At 21 d and 115 d of birth, there was no significant difference in the escape latency of water maze test between the experimental group and the control group (P> 0.05). Conclusion: The use of magnesium sulfate during the second trimester had no significant effect on the learning and memory abilities of experimental offspring.