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目的探讨9号染色体臂间倒位[inv(9)]与不良孕产史的关系,分析9号染色体臂间倒位的遗传效应。方法对2007年1月至2010年4月来我院就诊的1189例患者进行外周血淋巴细胞培养,按常规方法制备染色体,应用G、C显带技术进行核型分析。结果 1189例受检者中,共检出inv(9)29例,检出率为2.44%,其中967例不良孕产史患者中检出inv(9)29例,检出率3.00%,占阳性人数的100%,129例正常孕前体检者及93例原发不孕及闭经患者未检出inv(9),经χ2检验,不良孕产史者与正常孕前体检者之间inv(9)的发生率比较有显著差异(P<0.05)。结论 inv(9)可导致不良孕产史的发生。
Objective To investigate the relationship between involution of chromosome 9 (inv (9)) and the history of adverse pregnancy and to analyze the genetic effect of internodal inversion on chromosome 9. Methods Peripheral blood lymphocytes were cultured in 1189 patients who came to our hospital from January 2007 to April 2010. Chromosomes were prepared by routine methods and analyzed by G, C banding technique. Results Of the 1189 subjects, 29 (9) inv (9) were detected, with a detection rate of 2.44%. Among 967 patients with unwanted pregnancy history, 29 (9) were detected as inv (9), with a detection rate of 3.00% Inv (9) were not found in 129 normal pregnant women and 93 primary infertility patients and in amenorrhea patients. There was no significant difference in inv (9) between the two groups The incidence was significantly different (P <0.05). Conclusion Inv (9) can lead to the occurrence of adverse pregnancy history.