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心肌缺血的再灌注治疗一方面恢复了心肌的血供,另一方面可能加重缺血心肌的损伤。心肌缺血/再灌注损伤一直以来是心血管医疗工作者的焦点问题。在保证再灌注治疗的心肌保护作用不受影响的情况下,如何减少再灌注损伤,国内外研究者们历经了艰辛的探索,相继提出了心肌缺血预适应-心肌药物预适应-心肌缺血后适应-心肌药物后适应的概念。该文就当今这一研究新热点及其发生、发展过程和心肌保护作用机制等进行综述。
Reperfusion therapy of myocardial ischemia on the one hand to restore the blood supply of myocardium, on the other hand may aggravate ischemic myocardial injury. Myocardial ischemia / reperfusion injury has long been a focus of cardiovascular medical workers. How to reduce the reperfusion injury under the circumstance that the myocardial protective effect of reperfusion therapy is not affected, the researchers at home and abroad have gone through arduous exploration and put forward the myocardial ischemic preconditioning-myocardial drug preconditioning-myocardial ischemia After adaptation - concept of post-cardiac adaptation. This article summarizes the new hot spot in this research and its occurrence, development process and mechanism of myocardial protection.