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目的:分析探讨纤维支气管镜检查联合肿瘤标志物检测对肺癌的诊断价值。方法:对150例肺癌患者进行临床研究,按病情不同分为肺癌组和肺部良性病变组,均进行纤维支气管镜检查,并检测患者血清中的肿瘤标志物,观察并分析其临床检测结果。结果:肺癌组患者的糖类抗原、细胞角蛋白19片段21-1和癌胚抗原的阳性检出率分别是46.7%、55.6%和46.7%,明显高于肺部良性病变组的13.3%、15.6%和11.1%(P<0.05);肺癌组患者的纤维支气管镜诊断敏感度是55.6%,准确率为77.8%,特异度高达100%。纤维支气管镜联合肿瘤标志物检测的敏感度为95.6%,准确率为91.1%,特异度高达88.9%,均明显高于单一检查方式(P<0.05)。结论:使用纤维支气管镜联合肿瘤标志物检测肺癌有较高诊断价值,可以提高诊断的准确率。
Objective: To analyze the diagnostic value of fiberoptic bronchoscopy combined with tumor markers in the diagnosis of lung cancer. Methods: 150 cases of lung cancer patients were divided into two groups: lung cancer group and benign lung disease group. All patients underwent bronchofibroscopy and the tumor markers in serum were observed. The clinical results were analyzed and analyzed. Results: The positive rates of carbohydrate antigen, cytokeratin 19 fragment 21-1 and carcinoembryonic antigen in patients with lung cancer were 46.7%, 55.6% and 46.7% respectively, which were significantly higher than those in benign lung group (13.3%), 15.6% and 11.1% respectively (P <0.05). The diagnostic sensitivity of bronchoscopy in patients with lung cancer was 55.6%, the accuracy was 77.8% and the specificity was 100%. The sensitivity of fiberoptic bronchoscopy combined with tumor markers was 95.6%, the accuracy was 91.1% and the specificity was 88.9%, which were significantly higher than that of single examination (P <0.05). Conclusion: The use of fiberoptic bronchoscopy combined with tumor markers in the detection of lung cancer has a higher diagnostic value, can improve the diagnostic accuracy.