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目的观察阿德福韦酯联合复方甘草酸苷治疗慢性乙型肝炎的疗效。方法对62例慢性乙型肝炎患者随机分为治疗组和对照组,治疗组给予阿德福韦酯联合复方甘草酸苷治疗,对照组给予阿德福韦酯治疗。结果 (1)两组治疗结束时ALT、AST与治疗前比较差异有显著性;(2)两组治疗结束后,0、6、12个月ALT复常率比较差异有显著性;(3)两组病例治疗结束后HBeAg/抗-HBe血清转换在第6、12个月时,治疗组优于对照组;HBV DNA阴转治疗结束后不同时间,两组比较差异均有显著性。结论慢性乙型肝炎患者使用阿德福韦酯联合复方甘草酸苷疗效优于单用阿德福韦酯。
Objective To observe the curative effect of adefovir dipivoxil combined with compound glycyrrhizin on chronic hepatitis B patients. Methods Sixty-two patients with chronic hepatitis B were randomly divided into treatment group and control group. The treatment group was treated with adefovir dipivoxil combined with compound glycyrrhizin, while the control group was treated with adefovir dipivoxil. Results (1) There was significant difference of ALT and AST between the two groups before treatment; (2) There was significant difference of ALT normalization rate between the two groups at 0, 6 and 12 months after treatment; (3) The HBeAg / anti-HBe seroconversion in the two groups was better than the control group at the 6th and 12th months after the treatment. The differences between the two groups were significant at different time points after the HBV DNA negative conversion. Conclusion Adefovir dipivoxil combined with compound glycyrrhizin is superior to adefovir dipivoxil alone in patients with chronic hepatitis B.