本文以ＬＢＰＩ／１小鼠为对象，就中药莪术对小鼠骨髓嗜多染红细胞微核及骨髓细胞姊妹染色单体互换（ＳＣＥ）频率的影响进行观察。结果表明，用高于临床常用最大剂量２－４倍的莪术煎液灌喂小鼠，小鼠骨髓嗜多染红细胞微核率及骨髓细胞ＳＣＥ频率均未见增高。提示莪术作为抗肿癌药物，未显示遗传毒性，可在临床广泛使用。 In this study, the effect of Curcuma zedoaria on the micronucleus of bone marrow erythroblasts and the sister chromatid exchange (SCE) frequency of bone marrow cells was observed in LBPI/1 mice. The results showed that mice fed with zhuzhi decoction, which was 2 to 4 times the maximum dose commonly used in clinical practice, had no increase in micronuclear rate of bone marrow polychromatic erythrocytes and SCE frequency of bone marrow cells. It is suggested that Curcuma as an anti-tumor cancer drug does not show genetic toxicity and can be widely used in clinic.