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目的:观察祛瘀解毒法结合射频消融对大肠癌肝转移患者生存质量的影响。方法:将90例患者随机分为中医组、综合治疗组和射频消融组各30例,采用生命质量测定量表FACT-C(V4.0)中文版对身体状况、社会/家庭状况、情绪状况、功能状况、附加关注和量表总分6个指标进行观察分析。结果:治疗后3组身体状况、情绪状况、功能状况、附加关注以及量表总分评分分别比较,差异均有显著性意义(P<0.05)。经两两均数的SNK检验,除社会/家庭状况外,中医组和综合治疗组各项指标均优于射频消融组,差异均有显著性意义(P<0.05);且中医组各项指标与综合治疗组比较,差异均无显著性意义(P>0.05)。其中身体状况方面中医组的分值最高,相应的临床疗效最好,综合治疗组其次,射频消融组最低;情绪状况、功能状况、附加关注以及量表总分综合治疗组的分值最高,相应的临床疗效最好,中医组其次,射频消融组最低。结论:祛瘀解毒法结合射频消融可以改善大肠癌肝转移患者的生存质量,优于单纯中医药或射频消融治疗。
Objective: To observe the effect of removing blood stasis and detoxification combined with radiofrequency ablation on the quality of life of patients with liver metastasis from colorectal cancer. Methods: 90 patients were randomly divided into TCM group, comprehensive treatment group and radiofrequency ablation group and 30 patients respectively. The Chinese version of FACT-C (V4.0) was used to assess the physical status, social / family status, emotional status , Functional status, additional attention and the total score 6 indicators were observed and analyzed. Results: There were significant differences in physical status, emotional status, functional status, additional attention and total score of the three groups after treatment (P <0.05). The SNK test showed that the indexes of TCM group and comprehensive treatment group were superior to radiofrequency ablation group except for social / family status, with significant difference (P <0.05). The indexes of TCM group Compared with the comprehensive treatment group, there was no significant difference (P> 0.05). Among them, the scores of TCM group were the highest in physical condition, and the corresponding clinical outcomes were the best, followed by the combination therapy group and the lowest in radiofrequency ablation group. The scores of emotional state, functional status, additional attention and total score of comprehensive treatment group were the highest, The clinical efficacy of the best, followed by the Chinese medicine group, the lowest RF ablation group. Conclusion: Quyu detoxification combined with radiofrequency ablation can improve the quality of life of patients with liver metastasis of colorectal cancer, better than simple Chinese medicine or radiofrequency ablation.