妊娠是影响体内药动学和改变药效及其副作用程度的诸因素之一.机体随妊娠及其进展而产生的巨大生理变化,改变了孕妇体内药物的动力学参数,导致药物代谢及从孕妇体内排出减慢.半合成氨苄青霉素和先锋霉素对母亲和胎儿最无害且有效,因此,很有必要研究这类药物在孕妇体内药动学的特点. Pregnancy is one of the factors that affect the pharmacokinetics and the efficacy and side effects of the body.Physiological changes in the body with pregnancy and its progress have changed the kinetic parameters of the drug in pregnant women, Slowed the body’s excretion of semi-synthetic ampicillin and cephalosporin on the mother and fetus the most harmless and effective, therefore, it is necessary to study the pharmacokinetics of these drugs in pregnant women.