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目的探讨非小细胞肺癌(NSCLC)与慢性阻塞性肺病(COPD)患者的血清C反应蛋白(CRP)水平变化。方法采用速率散射法检测NSCLC组(46例)、NSCLC合并COPD组(30例)、COPD组(60例)和健康体检者对照组(38例)血清CRP水平。结果 NSCLC组和NSCLC合并COPD组血清CRP水平明显高于COPD和对照组[(19.32±2.15)mg/L和(23.09±1.98)mg/Lvs.(8.67±1.31)mg/L和(2.79±0.77)mg/L](P<0.01)。早期NSCLC患者血清CRP水平明显低于晚期患者[(14.52±2.34)mg/L vs.(23.29±1.81)mg/L](P<0.01),但明显高于COPD组及对照组(P<0.01)。血清CRP水平与肺癌病理分型及吸烟无相关性。结论慢性炎症在NSCLC及COPD中扮演重要的角色,在NSCLC中尤为明显。
Objective To investigate the changes of serum C-reactive protein (CRP) levels in patients with non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD). Methods Serum CRP levels were detected by velocity scattering in 46 NSCLC patients, 30 NSCLC patients with COPD, 60 COPD patients and 38 healthy controls. Results Serum levels of CRP in NSCLC group and NSCLC with COPD group were significantly higher than those in COPD group and control group [(19.32 ± 2.15) mg / L and (23.09 ± 1.98) mg / L vs (8.67 ± 1.31) mg / L and ) mg / L] (P <0.01). Serum CRP levels in patients with early stage NSCLC were significantly lower than those in patients with advanced stage [(14.52 ± 2.34) mg / L vs. (23.29 ± 1.81) mg / L], P <0.01 ). There was no correlation between serum CRP level and pathological type of lung cancer and smoking. Conclusion Chronic inflammation plays an important role in NSCLC and COPD, especially in NSCLC.