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又聚乙烯二醇（PEG）制剂伊曲康ap（ITZ）原药解离常数PKa为3．7。是碱性极弱的化合物，在胃酸低PH条件下溶解度约4ug／mlo因此ITZ原药口服给药后，在消化道几乎不吸收。为了增加口服吸收，作者首先着眼于ITZ可溶解干PEG中，将其制成充填干硬明胶胶囊中的制剂（PEG制剂）。将健
And polyethylene glycol (PEG) formulations Itracon ap (ITZ) the original drug dissociation constant PKa 3.7. Is a very weakly basic compound with a solubility of about 4 ug / mL at low pH of gastric acid. Therefore, the ITZ drug is almost not absorbed in the digestive tract after its oral administration. In order to increase oral absorption, the authors first looked at ITZ dissolvable dry PEG, which is made into a formulation (PEG formulation) filled in dry hard gelatin capsules. Will be healthy