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１９９４年３月～１９９７年５月间，我们对１１１例开放性骨折患者在急诊清创时随机分成Ａ、Ｂ两组，Ａ组单用３％过氧化氢浓液清洗伤口，Ｂ组除用３％过氧化氢溶液外，加用０．１％洗必泰水溶液清洗伤口。对两组病例出现的感染率进行比较。结果显示：Ⅰ、Ⅱ度开放性骨折两种方法无统计学差异（Ｐ＞０．０５），而Ⅲ度开放性骨折有显著差异（Ｐ＜０．０１），Ｂ组优于Ａ组。建议在Ⅲ度开放性骨折清创时，可常规联合应用３％过氧化氢溶液和０．１％洗必泰水溶液清洗伤口。
Between March 1994 and May 1997, 111 patients with open fractures were randomly divided into two groups A and B during emergency debridement. Group A washes the wounds with only 3% hydrogen peroxide concentrate, while group B used only 3% hydrogen peroxide solution, add 0.1% chlorhexidine aqueous solution to clean the wound. The incidence of infection in both groups was compared. The results showed that there was no significant difference between the two methods (P> 0.05). There was significant difference between open fractures of Ⅲ degree (P <0.01). Proposed open debridement in the third degree of debridement, the routine combination of 3% hydrogen peroxide solution and 0.1% chlorhexidine solution wound cleaning.