欧洲《糖尿病学》杂志第18卷第3期(1980年)第255页报道意大利罗马大学内分泌教授Dumenico Andreani致编辑部的一封信。在信中Andreani提出对糖尿病恶性微血管病变的有关看法。关于糖尿病微血管基底膜增厚的争论,作者强调了他的意见并希望能引起重视。作者认为,毫无疑问,微血管基底膜增厚的病变是随着病程而进展的,在糖尿病发生15～20年以后,80％以上的糖尿病病人的微血管基底膜明显增厚。然而,糖尿病微血管病变的临床过程多种多样,有些病人在糖尿病发生20年后,在临床上并不出现眼或肾的病变。而这些病人绝大部份是有代谢紊乱并已获得控制,尤其是每日注射3～4针短效胰岛素者;或未用 European Journal of Diabetes Volume 18, Number 3 (1980) Page 255 Report Dumenico Andreani, Endocrinology Professor, University of Rome, Italy, to the editorial board. In the letter Andreani put forward the views on diabetic malignant microangiopathy. With regard to the debate about the thickening of the diabetic microvascular basement membrane, the author emphasizes his opinion and hopes to draw attention. The authors believe that there is no doubt that the thickening of the capillary basement membrane lesions progress with the course of diabetes in the 15 to 20 years later, more than 80% of diabetic patients with microvascular basement membrane was significantly thicker. However, the clinical course of diabetic microangiopathy is varied, and some patients do not clinically have ocular or renal lesions after 20 years of diabetes. The vast majority of these patients have metabolic disorders and have been controlled, especially daily injection of 3 to 4 short-acting insulin; or unused