论文部分内容阅读
目的:探讨C 反应蛋白(CRP)对ST段抬高型急性心肌梗死(AMI)静脉溶栓疗效的作用。方法:31例 ST段抬高型AMI患者根据静脉溶栓前血清CRP水平分为3组,比较静脉溶栓后2 h内ST段回落、10 d后冠状动脉造影示梗死相关血管血流TIMI分级及冠状动脉病变情况,筛选影响静脉溶栓的因子,评估 2 h内 ST段回落与10 d后冠状动脉造影示梗死相关血管血流 TIMI分级的相关性。结果:静脉溶栓前血清 CRP浓度越高,溶栓后2 h内ST段回落≥50%和冠状动脉造影所示梗死相关血管血流达到TIMI 3及的越少(P<0.05),冠状动脉多支病变增多(P<0.05)。2 h内ST段回落与10 d后冠状动脉造影示梗死相关血管血流 TIMI分级具有相关性( r=0.42,P<0.05)。结论:CRP是影响静脉溶栓成功的因子之一,静脉溶栓前血清CRP浓度升高可能影响静脉溶栓的疗效。
Objective: To investigate the effect of C-reactive protein (CRP) on thrombolytic therapy in patients with ST-elevation acute myocardial infarction (AMI). Methods: Thirty-one ST-segment elevation AMI patients were divided into three groups according to the level of serum CRP before intravenous thrombolysis, compared with ST-segment drop within 2 h after intravenous thrombolysis. Coronary angiography showed infarct- And coronary artery lesions, screening for factors affecting venous thrombolysis, assessment of 2 h ST segment regression and coronary angiography 10 days after infarction related vascular flow TIMI grade correlation. Results: The higher serum CRP concentration before intravenous thrombolysis, the more than 50% ST segment regression within 2 h after thrombolysis and the less infarct-related vascular blood flow (P <0.05) in coronary angiography and coronary artery Multivessel disease increased (P <0.05). The regression of ST segment within 2 h was correlated with TIMI classification of infarct-related vascular flow 10 days after coronary angiography (r = 0.42, P <0.05). CONCLUSION: CRP is one of the factors affecting the success of intravenous thrombolysis. The increase of serum CRP concentration before intravenous thrombolysis may affect the efficacy of intravenous thrombolysis.