以L-丝氨酸和α-酮戊二酸为原料,采用三条合成路线,经6～8步反应,合成8个目标化合物。其部份中间体的结构经IR,PMR,MS及元素分析证实。产物的结构也经IR及PMR证实。体外抑菌试验表明,TM7和TM8显示较强的广谱抑菌活性,TM6则具有中等强度。TM2和TM3对金葡菌也有一定活性。 Using L-serine and α-ketoglutaric acid as raw materials, three synthetic routes were used to synthesize eight target compounds after 6-8 steps. The structure of some of its intermediates was confirmed by IR, PMR, MS and elemental analysis. The structure of the product was also confirmed by IR and PMR. In vitro bacteriostatic test showed that TM7 and TM8 showed strong broad-spectrum antibacterial activity, while TM6 had moderate intensity. TM2 and TM3 also have some activity against Staphylococcus aureus.