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目的探讨术中冰冻切片在卵巢交界性肿瘤(BOTs)诊断中的意义。方法收集天津市中心妇产科医院2011年1月-2012年12月收治的129例BOTs患者的病历资料,并对该资料的临床特点、诊治情况及术后复发情况等进行回顾性分析。结果患者冰冻切片与石蜡切片病理诊断符合率为79.37%,主要影响因素有病理类型和肿物大小。诊断不符者中病理类型以黏液性卵巢交界性肿瘤(MBOT)为主(19例,73.08%),直径>10 cm者较≤10 cm者诊断符合率低(64.44%vs.87.65%),差异有统计学意义(P=0.002)。复发者以双侧肿物、期别较高、具有微乳头、浸润性种植及未行全面分期手术者多见。大网膜转移6例(4.65%),盆腔淋巴结转移1例,再分期手术7例,术后病理分期均未见上升。结论 MBOT及肿物直径>10 cm者冰冻切片与术后石蜡病理诊断符合率较低,应引起临床及病理医师的注意。复发的相关因素为双侧肿物、分期、微乳头、浸润性种植及是否行全面分期手术。建议Ⅰ期患者可适当保留大网膜,淋巴结是否常规切除有待进一步讨论。初次手术未行全面分期者应充分与患者沟通后再决定是否行再分期手术。
Objective To investigate the significance of intraoperative frozen sections in the diagnosis of borderline ovarian tumors (BOTs). Methods The data of 129 cases of BOTs admitted from January 2011 to December 2012 in Tianjin Obstetrics and Gynecology Hospital were collected and analyzed retrospectively. The clinical features, diagnosis and treatment and postoperative recurrence were analyzed retrospectively. Results The coincidence rate of frozen section and paraffin sections was 79.37%. The main influencing factors were pathological type and tumor size. Misdiagnosis of the pathological type of mucinous borderline ovarian tumors (MBOT) (19 cases, 73.08%), diameter> 10 cm were less than 10 cm diagnosis of low coincidence rate (64.44% vs.87.65%), the difference There was statistical significance (P = 0.002). Recurrence to bilateral tumor, the higher the period, with a micro-nipple, invasive implantation and not fully staged surgery were more common. Omental metastasis in 6 cases (4.65%), pelvic lymph node metastasis in 1 case, re-staging surgery in 7 cases, postoperative pathological staging were not increased. Conclusions MBOT and frozen section with tumor diameter> 10 cm have a low coincidence rate with postoperative paraffin pathological diagnosis, which should be paid attention to by clinicians and pathologists. Relevant factors for recurrence of bilateral tumor, staging, micro-nipple, invasive implantation and whether to undergo a comprehensive staging. Proposed stage Ⅰ patients may be properly retained the omentum, lymph nodes conventional excision needs further discussion. The first surgery was not fully staged should fully communicate with the patient before deciding whether to undergo the re-staging surgery.