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缺氧诱导因子-1(hypoxia inducible factor-1,HIF-1)是一个普遍存在于人和哺乳动物细胞内的缺氧应答因子,是细胞在缺氧环境下重要的转录因子[1]。HIF-1是缺氧诱导基因转录的关键环节,而且是缺氧诱导基因转录过程中缺氧信息传递的共同通路[2]。HIF-1的发现使人们对缺血、缺氧状
Hypoxia inducible factor-1 (HIF-1) is a hypoxia-responsive transcription factor commonly found in human and mammalian cells and an important transcription factor in hypoxia [1]. HIF-1 is a key part of hypoxia-induced gene transcription and is the common pathway of hypoxia information transmission during hypoxia-induced gene transcription [2]. The discovery of HIF-1 renders people ischemic and hypoxic