重型乙型肝炎病情进展迅猛,病死率高,严重危害人类健康。其发病机制复杂,本文主要从病毒因素和宿主因素两方面进行综述,包括病毒基因型、病毒变异以及免疫反应与细胞因子等近年来重型乙型肝炎发病机制的研究进展,为更深入地了解其发病机制以及在今后的临床诊疗中寻找新的靶点提供参考。 Hepatitis B disease progresses rapidly, mortality is high, seriously endangering human health. Its pathogenesis is complex. This article mainly reviewed the viral factors and host factors, including the progress of virus genotype, virus mutation and immune response and cytokines in the pathogenesis of severe hepatitis B in recent years. In order to know more about the pathogenesis of severe hepatitis B, Pathogenesis and in the future clinical diagnosis and treatment to find new targets for reference.