论文部分内容阅读
目的:比较甲巯咪唑(MMI)持续减量的给药方法与传统大剂量的服用对甲状腺功能亢进症的疗效。方法:选取重庆市永川区人民医院2012年6月至2015年6月就诊的甲状腺功能亢进症患者56例,给予MMI治疗并观察疗效。观察组28例患者根据促甲状腺素(TSH)的变化情况调整MMI治疗剂量,按15 mg/d,10 mg/d,5 mg/d,2.5 mg/d,1.25mg/d,0.625 mg/d,0mg/d持续递减给药;对照组28例患者按传统MMI给药方法,首剂量30 mg/d,至维持量10 mg/d时持续服用1.5~2年后停药。结果:两组MMI的治疗有效率比较,差异无统计学意义(P>0.05),但观察组1~2年的复发率和不良反应的发生率与对照组比较,差异具有统计学意义(P<0.05)。结论:MMI用于治疗甲状腺功能亢患者,采用持续减量的给药方式优于传统的给药方式,可能是一种更科学合理的给药方式。
OBJECTIVE: To compare the efficacy of sustained-dose administration of methimazole (MMI) with traditional high-dose administration of hyperthyroidism. Methods: Fifty-six hyperthyroidism patients from June 2012 to June 2015 in Yongchuan District People’s Hospital of Chongqing were treated with MMI and the curative effect was observed. In the observation group, 28 patients were treated with 15 mg / d, 10 mg / d, 5 mg / d, 2.5 mg / d, 1.25 mg / d and 0.625 mg / d according to the change of thyrotropin (TSH) , 0mg / d continuous decreasing administration; control group of 28 patients according to the traditional MMI administration method, the first dose of 30 mg / d, to maintain the amount of 10 mg / d continued taking 1.5 to 2 years after the withdrawal. Results: There was no significant difference in the treatment effective rate between the two groups (P> 0.05), but the recurrence rate and the incidence of adverse reactions in the observation group between 1 and 2 years were significantly higher than those in the control group (P <0.05). Conclusion: MMI is a more scientific and rational way to treat hyperthyroidism patients.