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吸入皮质醇疗法是哮喘患者常用疗法,而且需长期使用。在英国1/3哮喘患者定期使用吸入皮质醇,其中1/3的人每天吸入800μg或更多。吸入给药是通过气体途径起作用,产生的不利影响少于口服途径。但是吸入的皮质醇可从肺吸收入循环系统,与胃肠道途径相比其变化更大。现已证明其使用和挫伤、白内障及青光眼有关系,其对骨是否有重要的临床影响以及有多大程度的影响还不能确定。由于皮质醇吸入疗法被广泛应用,骨质疏松症也很普遍,所以在这方面的研究对公众健康有重要意义。
Inhaled cortisol therapy is a common therapy for asthmatics and requires long-term use. In the United Kingdom, 1/3 asthma sufferers regularly inhaled cortisol, of which 1/3 inhaled 800 μg or more per day. Inhalation administration works through the gas route, with less adverse effects than the oral route. However, inhaled cortisol can be taken up from the lungs into the circulatory system, which is more variable than the gastrointestinal tract. It has been demonstrated that its use is associated with contusion, cataracts and glaucoma, and it remains unclear whether there is an important clinical impact on the bone and to what extent. As Cortisol inhalation therapy is widely used, osteoporosis is also common, so research in this area is of great importance to public health.