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在 Th细胞向 Th1/Th2细胞分化过程中，白介素 12(IL－ 12)是决定免疫反应的性质和功效的关键性细胞因子 [1,2]，它甚至可以使1已建立的 Th2型为主的反应向 Th1型转变 [3]。我们的实验表明系统性红斑狼疮 (SLE)患者 IL－ 12水平降低主要由单一核细胞分泌能力下降引起，而 IL－ 1
Interleukin 12 (IL-12) is a key cytokine that determines the nature and efficacy of an immune response during differentiation of Th cells into Th1 / Th2 cells [1,2], and may even predominate 1 established Th2 type Of the reaction to Th1-type transition [3]. Our experiments show that the decrease of IL-12 level in patients with systemic lupus erythematosus (SLE) is mainly caused by the decrease of the secretion capacity of mononuclear cells, while IL-1