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目的:回顾性分析同步放化疗治疗局部晚期宫颈癌的临床效果及不良反应情况。方法:收集2004年6月至2009年5月入我院治疗的Ⅱb-Ⅲb期宫颈癌患者,随机分成同步放化疗组(A组,n=56)及单纯放疗组(B组,n=54),分析A、B组的治疗疗效和不良反应。结果:A组治疗有效率(85.71%)较B组(61.11%)高(P<0.05);A组与B组间不良反应(如骨髓抑制和胃肠道反应)发生率无明显差别(P>0.05)。结论:同步放化疗治疗局部晚期子宫颈癌可有效地控制肿瘤发展,提高患者5年生存率。
Objective: To retrospectively analyze the clinical effects and adverse reactions of concurrent chemoradiotherapy in the treatment of locally advanced cervical cancer. Methods: Patients with stage Ⅱb-Ⅲb cervical cancer who were admitted to our hospital from June 2004 to May 2009 were randomly divided into concurrent radiochemotherapy (group A, n = 56) and radiotherapy alone (group B, n = 54 ), Analysis of A, B treatment efficacy and adverse reactions. Results: The effective rate of treatment in group A (85.71%) was higher than that in group B (61.11%) (P <0.05). There was no significant difference in the incidence of adverse reactions (such as myelosuppression and gastrointestinal reaction) between group A and group B > 0.05). Conclusion: Chemotherapy with concurrent chemoradiotherapy can effectively control tumor development and improve 5-year survival rate in patients with locally advanced cervical cancer.