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用含氟３２０ｍｇ／ｋｇ饲料和含维生素Ｃ６００ｍｇ／１００ｍｌ刺梨汁饮水饲养Ｗｉｓｔａｒ大鼠６个月，探讨刺梨汁对慢性氟中毒的影响及其机理。结果发现刺梨汁具有明显改善慢性氟中毒的一般状况，减少氟斑牙的形成，增加氟中毒大鼠的体重，促进尿氟排泄，降低血清和骨氟含量，提高血清维生素Ｃ含量，保护胶原组织，使尿羟脯氨酸含量降低，通过提高血清维生素Ｅ和ＧＳＨ含量，增强血ＧＳＨ－Ｐｘ和ＳＯＤ活性而抑制氟中毒引起的脂质过氧化，从而降低血清ＬＰＯ含量。提示刺梨汁具有明显拮抗慢性氟中毒作用，其机理是通过促进尿氟排泄和拮抗慢性氟中毒的脂质过氧化作用。
Wistar rats were bred for 6 months with fluoride containing 320mg / kg feed and vitamin C 600mg / 100ml cinnabar juice to investigate the effect and mechanism of Cili juice on chronic fluorosis. The results showed that Cili pear juice can significantly improve the general status of chronic fluorosis, reduce the formation of dental fluorosis, increase the body weight of fluorosis rats, promote urinary fluoride excretion, lower serum and bone fluoride levels, increase serum vitamin C content, protect collagen Organization, so that the content of urinary hydroxyproline decreased, by increasing serum vitamin E and GSH content, increase blood GSH-Px and SOD activity and inhibit fluoride poisoning caused by lipid peroxidation, thereby reducing serum LPO content. Tip Cili pear juice has obvious antagonism of chronic fluorosis, the mechanism is through the promotion of urinary fluoride excretion and antagonize chronic fluorosis of lipid peroxidation.