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目的 探讨血小板膜 Ｂｃｌ－ ２ 对缺血区神经细胞凋亡作用与脑梗塞灶形成的联系。方法 采用流式细胞仪检测３１ 例急性脑梗塞患者血浆中血小板 Ｂｃｌ－ ２ 百分含量。结果 健康对照组血浆中血小板膜 Ｂｃｌ－ ２ 百分含量以０９１ ±０６ 显著低于急性脑梗塞组的２６６ ±１４ ， Ｐ＜ ００５ 。结论 Ｂｃｌ－ ２ 百分含量增高与脑梗塞时神经细胞存活密切相关；可能是脑缺血区神经细胞自我保护机制之一，因此， Ｂｃｌ－ ２ 含量异常可作为早期诊断治疗脑梗塞的客观依据。
Objective To investigate the effect of Bcl-2 on the apoptosis of ischemic neuronal cells and the formation of cerebral infarction. Methods Flow cytometry was used to detect plasma Bcl-2 in plasma from 31 patients with acute cerebral infarction. Results The percentages of plasma Bcl-2 in the plasma of the healthy control group were significantly lower than those of the acute cerebral infarction group (091 ± 06, 266 ± 14, P <005). Conclusions The increase of Bcl-2 is closely related to the survival of nerve cells in cerebral infarction. It may be one of the mechanisms of neuroprotection in cerebral ischemia. Therefore, the abnormal Bcl-2 content may serve as an objective basis for early diagnosis and treatment of cerebral infarction.