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黄体生成素释放因子(LRF)为一十肽,在下丘脑中合成和贮存。它作用于垂体,刺激黄体生成素(LH)和促卵泡素(FSH)的合成及释放。最近作者采用放射免疫测定和荧光显微镜术在人胎盘中发现具有免疫反应性的LRF。免疫荧光试验显示胎盘LRF(pLRF)存在于胎盘绒毛的细胞滋养层,而在合体滋养层中则无。放射免疫测定指出人胎盘PLRF浓度依妊娠期的长短而异,与胎儿的性别无关。胎盘内有大量pLRF,作者认为胎盘可能是妊娠期间这个因子的下丘脑外的
Luteinizing hormone releasing factor (LRF), a decapeptide, is synthesized and stored in the hypothalamus. It acts on the pituitary to stimulate the synthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Recently the authors found immunoreactive LRF in human placenta using radioimmunoassay and fluorescence microscopy. Immunofluorescence tests showed that placental LRF (pLRF) is present in the cytotrophoblast of placental villi and absent in syncytiotrophoblasts. Radioimmunoassay showed that the concentration of human placenta PLRF varies with the length of pregnancy, and has nothing to do with the sex of the fetus. The placenta has a large number of pLRF, the author believes that the placenta may be during pregnancy this factor hypothalamic