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目的：为探求清开灵注射液治疗中风的机制。方法：以家兔自体血凝块复制脑出血模型，用干湿比重法及原子吸收分光光度计分别检测脑组织水份与Ｎａ~＋、Ｋ~＋、Ｃａ~２＋Ｍｇ~２＋含量，并用伊文斯蓝（Ｅｖａｎｓｂｌｕｅ，ＥＢ）观察血脑屏障（ｂｌｏｏｄ－ｂｒａｉｎｂａｒｒｉｅｒ，ＢＢＢ）通透性变化。结果：脑血肿形成后，脑组织水、Ｎａ~＋、ｃａ~２＋、ＥＢ含量明显增加，Ｋ~＋、Ｍｇ~２＋降低，并有过度通气的血气值变化。ＥＢ含量的升高，反映出ＢＢＢ受损，通透性增高。结论：清开灵注射液能显著改善血气异常，降低ＢＢＢ通透性，促进脑组织内血肿的吸收，对脑水肿有明显的防治作用。
Objective: To explore the mechanism of qingkailing injection in treating stroke. Methods: The model of intracerebral hemorrhage was reproduced with autologous blood clot in rabbits. The contents of water and contents of Na ~ +, K ~ +, Ca ~ 2 + Mg ~ 2 in brain tissue were detected by dry weight ratio and atomic absorption spectrophotometer respectively. The changes of permeability of blood-brain barrier (BBB) were observed with Evansblue (EB). Results: After the formation of cerebral hematoma, the content of Na ~ +, Ca ~ 2 +, EB in brain tissue increased obviously, while K ~ +, Mg ~ 2 + decreased and hyperventilation changed. The increase in EB reflects the impaired BBB and increased permeability. Conclusion: Qingkailing injection can significantly improve blood gas abnormalities, reduce the permeability of BBB and promote the absorption of hematoma in brain tissue, which has a significant preventive and therapeutic effect on cerebral edema.