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目的探讨 2型糖尿病患者的红细胞免疫功能。方法运用酶免疫测定法 (EIA)检测 2型糖尿病 36例及正常对照组 30例 ,对比观察两组对象的红细胞免疫粘附性 (RCIA)及红细胞膜免疫复合物 (CIConRM) ,并将糖尿病组RCIA与临床代谢指标进行直线相关分析。结果糖尿病组RCIA及CICOnRM均显著低于正常对照组 (P <0 0 1及P <0 0 5 ) ,RCIA与病程及HbAlc成负相关 (P <0 0 1)。结论糖尿病患者存在红细胞免疫功能下降 ,其下降与病程及糖代谢控制不良有关。
Objective To investigate the erythrocyte immune function in type 2 diabetic patients. Methods 36 cases of type 2 diabetes mellitus and 30 cases of normal control group were detected by enzyme immunoassay (EIA). The RCIA and erythrocyte membrane immunocomplex (CIConRM) of the two groups were compared. The diabetic group RCIA and clinical metabolic indicators for linear correlation analysis. Results The RCIA and CICOnRM in diabetic patients were significantly lower than those in normal controls (P <0.01 and P <0.05). The RCIA was negatively correlated with duration of disease and HbAlc (P <0.01). Conclusion There is a drop of erythrocyte immune function in diabetic patients, which is related to the course of disease and the poor control of glucose metabolism.