目的铁过量可以增加氧化应激,在血管炎症和动脉粥样硬化形成中具有重要的作用。观察铁螯合剂去铁敏(DFO)是否可以改善局部炎症鼠模型的氧化应激和细胞粘附分子的表达。方法用空气注射C57BL/6J鼠产生背侧气囊。连续两天将DFO(100mg/kg)注入气囊,接着注入脂多糖(2.5mg/kg)。24h后 Excessive iron overload can increase oxidative stress and play an important role in the formation of vascular inflammation and atherosclerosis. To investigate whether iron-chelator deferoxamine (DFO) can improve oxidative stress and expression of cell adhesion molecules in a mouse model of local inflammation. Methods C57BL / 6J mice were injected with air to produce dorsal air sacs. DFO (100 mg / kg) was infused into the balloon on two consecutive days, followed by lipopolysaccharide (2.5 mg / kg). After 24h