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目的观察化疗前食管鳞癌组织中细胞周期素A的表达对紫杉醇化疗疗效的影响。方法采用免疫组化法检查48例初治食管鳞癌组织中细胞周期素A的表达。患者接受含紫杉醇为主的方案化疗两周期后评价近期疗效,随访3年生存期。结果细胞周期素A表达阳性患者化疗有效率54.8%,高于表达阴性患者的23.5%(P<0.05)。肿瘤分期、分化程度、细胞周期素A的表达是影响食管鳞癌预后的独立因素。结论细胞周期素A表达阳性的食管鳞癌患者对紫杉醇有较高的敏感性,可以作为预测紫杉醇疗效的参考指标。
Objective To observe the effect of paclitaxel chemotherapy on the expression of cyclin A in esophageal squamous cell carcinoma before chemotherapy. Methods Immunohistochemistry was used to examine the expression of cyclin A in 48 newly diagnosed esophageal squamous cell carcinomas. Patients receiving paclitaxel-based regimens were evaluated after two cycles of chemotherapy, with a 3-year follow-up of survival. Results The positive rate of chemotherapy in patients with positive cyclin A expression was 54.8%, which was higher than that in patients with negative expression (23.5%, P <0.05). Tumor stage, degree of differentiation, cyclin A expression is an independent factor affecting the prognosis of esophageal squamous cell carcinoma. Conclusions Patients with esophageal squamous cell carcinoma with positive expression of cyclin A have higher sensitivity to paclitaxel and may be used as a reference index to predict the efficacy of paclitaxel.