本文报道76例新生儿缺氧缺血性脑病（HIE）临床表现与眼底异常并进行分析。HIE时眼底改变包括视乳头水肿、视网膜水肿、视网膜血管改变及出血等，阳性率为55．26％，以重度HIE时变化明显。尽管HIE患儿脑水肿症状不典型，临床表现与眼底变化不相平行，但前囱膨隆或张力增高、抽搐等症状与眼底异常二者结合分析，可及时发现颅高压的新生儿。 This article reports 76 cases of neonatal hypoxic-ischemic encephalopathy (HIE) clinical manifestations and fundus abnormalities were analyzed. HIE fundus changes include papilledema, retinal edema, retinal vascular changes and bleeding, the positive rate was 55.26%, with significant changes in severe HIE. Although the symptoms of cerebral edema in children with HIE are not typical, clinical manifestations and fundus changes are not parallel, but the anterior bullae or tension increases, convulsions and other symptoms combined with fundus anomalies can be found in time neonates with intracranial hypertension.