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3-去酮双氢甲基睾丸素(17α-甲基-5α-雄甾烷-17β-羟基,简称3-去酮HMT)系一蛋白同化作用较强的同化类固醇.本文研究了其某些药理作用,结果如下:(1)3-去酮HMT促进去势小鼠提肛肌海绵球肌和肾脏重量以及该两种组织内RNA含量的增加.(2)3-去酮HMT似无糖皮质激素样作用,同时也不增强或对抗皮质素的抗炎作用.(3)3-去酮HMT可显著降低饲喂含胆固醇饲料的大鼠肝胆固醇含量,而对血胆固醇水平无明显影响.(4)给小鼠注射乙硫氨酸和四氯化碳可引起脂肪肝,3-去酮HMT能对抗乙硫氨酸和四氯化碳的这一作用.(5)预先给予3-去酮HMT,雌大鼠戊巴比妥钠睡眠时间显著缩短,但对二乙基巴比妥钠睡眠时间无明显影响.由此认为,3-去酮HMT可能具有刺激肝脏药物转化酶的作用.
3-desone Hydroxymethyl testosterone (17α-methyl-5α-androstane-17β-hydroxy, abbreviated as 3-desone HMT) is one of the assimilation of steroid assimilation strong steroid.In this paper, some of its Pharmacological effects, the results are as follows: (1) 3-desone HMT promote ovariectomized muscular and kidney weight and the RNA content of both tissues increased (2) 3-desone HMT sugar-free Corticosteroid-like activity, but also did not enhance or antagonize the anti-inflammatory effect of cortisol. (3) 3-to-deacetone HMT significantly reduced the content of hepatic cholesterol in rats fed with cholesterol diet, but had no significant effect on the level of serum cholesterol. (4) Injection of ethionine and carbon tetrachloride into mice can cause fatty liver, 3-deketone HMT can antagonize this effect of ethionine and carbon tetrachloride. (5) Pre-given 3- Ketone HMT, female rat pentobarbital sodium sleep time significantly shortened, but sleep time of diethylbarbitam sodium had no significant effect.Therefore, 3 - desone HMT may have the role of stimulating hepatic drug-converting enzyme.