The concept of ‘drug holidays’ (defined as “...the structured interruption of pharmacological treatment...”[1]) in the management of attention deficit hyperactivity disorder (ADHD) is well established,but poorly researched[1].The question is whether there is indeed a justifiable basis for the practice.In the opinion piece by Professors Du and Wang[2],they argue that on the balance of available evidence it is not justified.Herein lies the issue-the evidence.In reality significant numbers of parents both report side effects[3] and stop medication intermittently[1],and many sufferers stop treatment prematurely[4] (generally due to adverse effects).