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表皮生长因子(EGF)系通过表皮生长因子受体(EGFR)而与细胞增殖、分化有关的因子之一。文献报导,EGF和EGFR表达与癌发育、增殖密切相关,EGFR表达与患者预后亦呈相关性。目前有关肺癌EGFR和EGF表达与临床病理因子相关性研究甚少,且与预后相关性也未明瞭。为此,作者对非小细胞肺癌应用免疫组化方法研究EGFR和EGF表达及其临床病理学意义。取手术切除非小细胞肺癌78例(腺癌42例,鳞癌29例,大细胞癌7例),标本冰冻切片,采用ABC法测定EGFR和EGF。
Epidermal growth factor (EGF) is one of factors involved in cell proliferation and differentiation through the epidermal growth factor receptor (EGFR). The literature reports that the expression of EGF and EGFR is closely related to the development and proliferation of cancer, and the expression of EGFR is also related to the prognosis of patients. At present, there is little research on the correlation between EGFR and EGF expression and clinicopathologic factors in lung cancer, and the correlation with prognosis is not known. To this end, the authors applied immunohistochemistry to study the expression of EGFR and EGF and their clinicopathological significance in non-small cell lung cancer. 78 cases of non-small cell lung cancer (adenocarcinoma, 29 cases of squamous cell carcinoma, and 7 cases of large cell carcinoma) were surgically resected. The specimens were cryosectioned and EGFR and EGF were measured by ABC method.