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自1985年在美国发生严重意外病例以来,人们已不再将周效磺胺——乙胺嘧啶联合应用预防疟疾。然而,该药物的治疗效果还是较明显的。较甲氟喹价廉,副作用小,并可替代甲氟喹。氯喹代用品之一——法西达的药物成份之一——乙胺嘧啶的耐药性已为人知,但在非洲周效磺胺——乙胺嘧啶联合用药的耐药性有待于确证。作者对法国的非洲侨居病例观察非洲恶性疟对法西达(Fansidar)的耐药性,以期在非洲合理应用此药,使抗疟获满意的效果。病例1,为1984年侨居法国的一名象牙海岸青年,体重65公斤,28岁,1987年回国旅游
Since the serious accidental cases in the United States in 1985, there has been no longer the combination of psoriasis and pyrimethamine for the prevention of malaria. However, the drug’s therapeutic effect is still more obvious. More inexpensive than mefloquine, side effects, and can replace mefloquine. The resistance of pyrimethamine, one of the ingredients of chloroquine, one of the ingredients of faxidone, is known but the drug resistance of the combination of sulfasalazine and pyrimethamine in Africa remains to be confirmed. The authors observed the resistance of Plasmodium falciparum to Fansidar in African expatriate cases in France in order to rationally use the drug in Africa to achieve satisfactory results in malaria control. Case 1, a 1984 Ivory Coast youth living in France, weighing 65 kg, 28 years of age, 1987 to return to travel