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目的:探讨高原地区体外受精-胚胎移植(IVF-ET)后早期妊娠丢失的相关因素。方法:回顾性分析2008年5月—2010年6月在我中心行体外受精-胚胎移植(IVF-ET)或单精子卵胞浆内注射(ICSI)后成功妊娠的253例患者的资料,根据妊娠结局分为早期妊娠丢失组和对照组,比较两组间患者年龄、流产次数、基础FSH、基础LH、基础E2、基础T、Gn用量、Gn天数、HCG日E2、HCG日P、内膜厚度、获卵数、孕胎数等的差异;比较IVF与ICSI两组间早期妊娠丢失率的差异及长方案、短方案两组间早期妊娠丢失率的差异。结果:高原地区早期妊娠丢失率与平原地区相似;早期妊娠丢失组的年龄高于对照组,丢失组的孕胎数、获卵数均低于对照组。结论:高原地区引起IVFET后妊娠丢失的原因复杂,可能与患者的年龄、孕胎数、获卵数等因素相关,与高原缺氧无关。
Objective: To explore the related factors of loss of early pregnancy after in vitro fertilization-embryo transfer (IVF-ET) in the plateau. METHODS: The data of 253 patients with successful pregnancy after in vitro fertilization-embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI) in our center from May 2008 to June 2010 were retrospectively analyzed. Pregnancy outcomes were divided into early pregnancy loss group and control group. The patients’ age, abortion frequency, basal FSH, basal LH, basal E2, basal T, Gn dosage, Gn days, HCG day E2, HCG day P, Thickness, the number of oocytes retrieved, the number of gestations and so on. The difference of early pregnancy loss between IVF and ICSI and the difference of the rate of early pregnancy loss between long-term and short-term regimens were compared. Results: The loss rate of early pregnancy in plateau area was similar to that in plain area. The age of lost group in early pregnancy was higher than that in control group. The number of lost fetus and oocyte in lost group were lower than that in control group. CONCLUSIONS: The causes of post-IVFET loss of pregnancy in the plateau are complex and may be related to the age, number of pregnancies, number of oocytes retrieved and other factors, but not to the lack of oxygen on the plateau.