肝豆状核变性系一种罕见的早年变性疾病。我们诊治24例(男女各12例,年龄13～63岁),其中3例有家族史。首发症状有痴笑、单肢或四肢抖动、颤动、语言含糊或寡语、流涎、步态不稳、肝区疼痛等。主要临床表现及体征:言语不清14例,静止性震颤13例,痴笑11例,精神症状10例,流涎7例,失语3例,吞咽困难1例。角膜K—F色素环阳性者22例,四肢强直痉挛15例, Wilson’s disease is a rare early degenerative disease. We treated 24 cases (12 males and 12 females, aged 13-63 years), of whom 3 had a family history. The first symptoms are silly, single limbs or limbs shaking, fibrillation, vague language or language, salivation, unstable gait, liver pain and so on. The main clinical manifestations and signs: unclear speech in 14 cases, resting tremor in 13 cases, 11 smoldering, psychiatric symptoms in 10 cases, salivation in 7 cases, 3 cases of aphasia, dysphagia in 1 case. Corneal K-F pigment ring positive in 22 cases, 15 cases of limbs tonic spasm,